Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection
نویسندگان
چکیده
منابع مشابه
Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection
The success of siRNA-based therapeutics highly depends on a safe and efficient delivery of siRNA into the cytosol. In this study, we post-modified the primary amines on dendritic polyglycerolamine (dPG-NH2) with different ratios of two relevant amino acids, namely, arginine (Arg) and histidine (His). To investigate the effects from introducing Arg and His to dPG, the resulting polyplexes of ami...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2015
ISSN: 1860-5397
DOI: 10.3762/bjoc.11.86